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Primary malignant tumors of the heart (mesotheliomas, fibrosarcomas, and angiosarcomas) are rare, and most cases of cancer-related pericarditis are caused by metastatic tumors of remote origin. Lung cancer is the most common cancer type that may be complicated by pericarditis. Other cancers often identified in pericarditis patients are lymphoma, leukemia, and malignant melanoma, in addition to breast, ovary, prostate, colon, gastric, kidney, and bladder cancer.
Plausible mechanisms linking cancer to development of pericarditis include direct infiltration by malignant cancer cells from proximate structures, pericardial hemorrhage, or spread of cancer cells through the bloodstream