In the genetic epidemiological analyses, however, there was no clear evidence of any net protective effect of moderate alcohol consumption against acute myocardial infarction or total coronary heart disease (figure 5). Across the whole range of genotype-predicted mean male alcohol intake, the RR per 280 g per week was 0·96 (95% CI 0·78–1·18, p=0·69) for acute myocardial infarction and 1·05 (0·94–1·17, p=0·40) for total coronary heart disease.