#deepmind #biology #ai

This is Biology's AlexNet moment! DeepMind solves a 50-year old problem in Protein Folding Prediction. AlphaFold 2 improves over DeepMind's 2018 AlphaFold system with a new architecture and massively outperforms all competition. In this Video, we take a look at how AlphaFold 1 works and what we can gather about AlphaFold 2 from the little information that's out there.

OUTLINE:
0:00 - Intro & Overview
3:10 - Proteins & Protein Folding
14:20 - AlphaFold 1 Overview
18:20 - Optimizing a differentiable geometric model at inference
25:40 - Learning the Spatial Graph Distance Matrix
31:20 - Multiple Sequence Alignment of Evolutionarily Similar Sequences
39:40 - Distance Matrix Output Results
43:45 - Guessing AlphaFold 2 (it's Transformers)
53:30 - Conclusion & Comments

AlphaFold 2 Blog: https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology
AlphaFold 1 Blog: https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery
AlphaFold 1…