Original antigenic sin, also known as antigenic imprinting or the Hoskins effect, refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.

1. По выбору любого; 2. Включение/выключение без редактирования вообще, без изменения одной буквы в ваших драгоценных хромосомах; 3. И ещё и полностью обратимое - включенный ген может быть позже выключен во всём организме, и наоборот; В Cell статья вышла 29 апреля, но он-лайн она с 9-го, и всё это…