Геном вируса похож на SARS, статья в Lancet:
Coronavirus Genome Sequencing Finds Distinct Genetic Differences From 2003 SARS Virus
Jan 29, 2020
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staff reporter
NEW YORK – Researchers at the Chinese Center for Disease Control and Prevention and their collaborators have sequenced the 2019 novel coronavirus (2019-nCoV) pathogen from patient samples and have found it to be genetically distinct from the severe acute respiratory syndrome (SARS) virus that caused an epidemic in 2002 and 2003, as well as from the Middle East respiratory syndrome (MERS) virus that was detected in 2012.
As they described on Wednesday in The Lancet, the researchers sequenced samples from bronchoalveolar lavage fluid and cultured isolates from nine inpatients, eight of whom had visited the Huanan seafood market in Wuhan, China. Four samples were sent to BGI for sequencing on the company's DNBSEQ-T7 platform. In addition, Chinese CDC researchers obtained complete and partial 2019-nCoV genome sequences from six of the samples (two from the same patient) using a combination of Sanger, Illumina, and Oxford Nanopore sequencing. Viral contigs were connected using Sanger sequencing to obtain the full-length genomes and the researchers determined the terminal regions by rapid amplification of the cDNA ends.
In all, they developed ten genome sequences of 2019-nCoV from the nine patients, eight of which were complete. They then performed a phylogenetic analysis of the 2019-nCoV genomes and other coronavirus genomes to determine the evolutionary history of the new virus and to help infer its likely origin.
"Notably, 2019-nCoV was closely related (with 88 percent identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21, collected in 2018 in Zhoushan, eastern China, but were more distant from SARS-CoV (about 79 percent) and MERS-CoV (about 50 percent)," the authors wrote. "Phylogenetic analysis revealed that 2019-nCoV fell within the subgenus Sarbecovirus of the genus Betacoronavirus, with a relatively long branch length to its closest relatives, bat-SL-CoVZC45 and bat-SL-CoVZXC21, and was genetically distinct from SARS-CoV."
https://www.genomeweb.com/genetic-research/coronavirus-genome-sequencing-finds-distinct-genetic-differences-2003-sars-virus#.XjMbhrfTU0M